With advances in regenerative medicine and orthobiologics, amniotic tissue–derived materials have gained increasing attention in rehabilitation and musculoskeletal medicine. Amniotic tissue provides a natural extracellular matrix (ECM) scaffold rich in structural components such as collagen, laminin, fibronectin, and proteoglycans. It may also retain various growth factors, cytokines, and matrix-regulating molecules that contribute to a biologically active tissue microenvironment.

Current research has explored amniotic tissue–derived materials across a range of musculoskeletal conditions, including knee osteoarthritis, plantar fascia disorders, Achilles tendinopathy, lateral epicondylitis, and injuries involving tendons, ligaments, and cartilage. Research focuses not only on the structural role of the natural ECM scaffold but also on its potential involvement in modulating inflammation, fibrosis, and the local tissue environment.

Amniotic tissue has therefore become an important biomaterial in rehabilitation and regenerative medicine research. Basic and clinical evidence in musculoskeletal applications continues to grow, while advances in processing technology aim to preserve the ECM structure and relevant biological components that support the tissue-repair environment.